Situated adjacent to Highlands Reserve Golf Club, Regal Palms Resort is located behind the Publix Shopping Plaza, 2 miles south of the intersection of Highway 27 and Highway 192.

From Orlando/Sanford Airport
- Follow signs to I4 West & continue towards Disney area (approx. 30 miles)
- Exit Highway 192 West and travel 9 miles to Highway 27
- Take Highway 27 South for 2 miles to Sand Mine Road (NOTE: Publix plaza will be on right)
- Turn Right on Sand Mine Road
- Entrance to the resort is located on the right, at 2700 Sand Mine Road

From Orlando International Airport
- Take 528 West (Beeline Expressway) for 8 miles to I4 West
- Continue on I4 West for another 8 miles
- Exit Highway 192 West and travel 9 miles to Highway 27
- Take Highway 27 South for 2 miles to Sand Mine Road (NOTE: Publix plaza will be on right)
- Turn Right on Sand Mine Road
- Entrance to the resort is located on the right, at 2700 Sand Mine Road

From I4 West - Tampa Area
- Exit Highway 27 North
- Take Highway 27 North for 8 miles to Sand Mine Road
- Turn left on Sand Mine Road
- Entrance to the resort is located on the right, at 2700 Sand Mine Road